Lymphomas are tumors of the lymph glands that can occur in anyone but are more common and more severe in people with HIV infection. In some people, the only symptoms of lymphoma are the constitutional symptoms. In other people, the symptoms of lymphoma are very large lymph glands in the neck, under the arms, or in the groin; these symptoms are more commonly caused by persistent generalized lymphadenopathy (PGL). In some people, the symptoms of lymphoma differ according to where in the body lymphoma occurs: lymphoma in the intestines causes pain and diarrhea; in the brain, focal neurologic problems; in the lung, pneumonia. In people with HIV infection, lymphomas often progress rapidly, more rapidly than they do in other people. Treatment is with radiation and with chemotherapy using the same drugs used for other types of tumors. The treatment is given by specialists, either radiation therapists or oncologists. The success of the treatment is variable; some people do extremely well. Curing lymphoma is increasingly likely, so talk to your physician about the side effects and potential benefits of each treatment.*141\191\2*